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Drug penetration in solid tumors


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Nat Rev Cancer. Aug;6(8) Drug penetration in solid tumours. Minchinton AI(1), Tannock IF. Author information: (1)Department of Medical.


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Drug penetration in solid tumors
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Drug penetration in solid tumors
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Description:Also there is a general trend for variation of drug concentration in the tumor. For instance in application of Verteporfin anticancer drug to patients and its activation by irradiation, Verteporfin produces highly reactive singlet oxygen which reacts within 40 nanoseconds and results in the destruction of membrane bound organelles within the cell. Their model predicted how new therapeutic agents alter the functional efficiency of the vasculature within the tumor tissue [ 38 ]. Please note that in this modeling we consider and analyze the drug concentration in the tumor only due to drug diffusion. Drug Concentration in the Tumor In order to study the drug penetration in the tumor, first we need to investigate about drug concentration in the tumor versus time.

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