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BLOOD IN THE URINE
Animal Models of Female Stress Urinary Incontinence
Description:This model would likely be most useful for testing treatments aimed specifically at restoring the function of smooth and striated muscle since each is damaged in the absence of physical trauma to the urethra. Regional lymph nodes and surgical margins were tumor-free. Ki increased in P0 but decreased in P1 denoting a process of adaptation of the tumor cells to the host environment. Likewise unilaterally transected animals had voiding efficiency and residual volume between that of bilaterally transected and sham operated rats, and they were significantly different from each. The unit also contains examples as to how these models may be employed for drug screening. Altogether, these data suggest that the xenograft establishment process may be accompanied by the selection of a more aggressive and proliferative phenotype characterized by a significant overexpression of Ki and p53 Table I.
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